Senior Scientist / Associate Director, T Cell Immunology

You will own T cell immunology strategy for oncology and autoimmunity cell-therapy programs. You will design, run, and interpret primary human T-cell assays; characterize gene-editing enzymes; and define candidate-selection criteria. You will lead in vivo mouse and NHP studies with CRO partners, direct pharmacology and safety work for IND-enabling studies, contribute to regulatory filings and agency interactions, and mentor scientists while building a small team.

Responsibilities

• Own T cell immunology strategy across oncology and autoimmunity programs
• Translate program goals into assay and study plans
• Lead mouse and NHP studies for PK/PD, biodistribution, persistence, and immunogenicity with CRO partners
• Drive pharmacology and safety components of IND-enabling work, including toxicology study design and CRO oversight
• Assess biodistribution and insertional mutagenesis and author regulatory filing sections
• Represent data in pre-IND and agency interactions, partner meetings, and internal governance
• Design, run, and interpret in vitro potency and specificity assays in primary human T cells and cell lines
• Mentor scientists and grow the team

Requirements

• PhD in immunology, molecular biology, bioengineering, or a related life-sciences field with substantial cell or gene therapy industry experience, or an MSc with equivalent hands-on experience
• 6+ years post-PhD experience for Senior Scientist or 9+ years for Associate Director
• Expertise in primary human T cell isolation, activation, expansion, transfection, transduction, and functional characterization
• Experience with gene editing in primary immune cells and measuring editing outcomes
• Expertise in multiparameter flow cytometry, including panel design and analysis
• Fluency with ddPCR, qPCR, NGS library preparation, QC, and on/off-target analytics
• Experience designing and overseeing in vivo mouse studies, including CRO management
• Excellent communication skills with internal and external stakeholders

Benefits

• Equity
• Healthcare
• Carrot Fertility with IVF stipend
• 401(k)
• Life insurance